[Download] "Topical Anti-Inflammatory Effect of Tirucallol, A Triterpene Isolated from Euphorbia Lactea Latex (Short Communication) (Report)" by Phytomedicine: International Journal of Phytotherapy & Phytopharmacology * Book PDF Kindle ePub Free

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Title: Topical Anti-Inflammatory Effect of Tirucallol, A Triterpene Isolated from Euphorbia Lactea Latex (Short Communication) (Report)
Author : Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
Release Date : January 01, 2010
Genre: Life Sciences,Books,Science & Nature,
Pages : * pages
Size : 209 KB

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ABSTRACT Latex from Euphorbia lactea (Euphorbiaceae), a native Dominican medicinal plant, is claimed to be useful in the treatment of inflammation. Topical application of tirucallol. a tetracyclic triterpene isolated from Euphorbia lacteal latex, suppressed ear edema in the mouse model in a dose-dependent manner, as well as affecting the influx of polymorphonuclear cells in response to topical application of 12-O-tetradecanoylphorbol-acetate (TPA) in the mouse ear. In addition, the effect of tirucallol, on some macrophage functions was analyzed in vitro. Non-toxic concentrations of tirucallol potently inhibited nitrite production in lipopolysaccharide-stimulated macrophages. Western blot analysis showed that nitric oxide reduction was a consequence of the inhibition of inducible nitric oxide synthetase expression although tirucallol slightly affected to prostaglandin [E.sub.2] ([PGE.sub.2]) generation.